Superoxide Dismutase Activities in Plasma of Patients with Breast Cancer

Fezzeh Elyasinia (1), Venus Chegini (2), Asieh Olfat-Bakhsh (3), Parvin Pasalar (4), Ali Aminian (5)
(1) Department of Surgery, Tehran University of Medical Sciences, Tehran, Iran,
(2) Department of Gynecology and Obstetrics, Tehran University of Medical Sciences, Tehran, Iran,
(3) Breast Cancer Research group, Iranian Academic Center for Education, Culture and Research, Tehran, Iran,
(4) Department of Biochemistry, Tehran University of Medical Sciences, Tehran, Iran,
(5) Bariatric and Metabolic Institute, Cleveland Clinic, Cleveland, Ohio, US
https://doi.org/10.19187/abc.20141269-72

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Numéro
Vol 1, No 2: August 2014
Soumise
septembre 22, 2015
Publié-e
août 31, 2014
Mots-clés :
    Superoxide radicals, oxidative stress, superoxide dismutase
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Résumé

Background: Superoxide radicals are produced during oxidative metabolic processes, and removed by superoxide dismutase (SOD) enzymes. Controversial results have been reported regarding the tissue and plasma concentration of SOD in patients with breast cancer.

Methods: Venous blood was obtained from study participants and activity of SOD enzyme was determined in 100 women. Comparison was made between 50 patients with breast cancer and 50 individuals in control group.

Results: The activities of SOD in patients with malignancy and control group were 553.56±53.67 U/gr Hb and 1218.60±98.55 U/gr Hb, respectively (P <0.001). Patients with higher stage and nuclear grade had lower SOD activity.

Conclusions: lower levels of SOD activity was observed in women with breast cancer compared to healthy individuals. Considering the existing controversy regarding the SOD level in breast cancer patients, further studies to explore the reason of these differences are warranted.

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Auteurs-es

Fezzeh Elyasinia
Department of Surgery, Tehran University of Medical Sciences, Tehran, Iran
Venus Chegini
Department of Gynecology and Obstetrics, Tehran University of Medical Sciences, Tehran, Iran
Asieh Olfat-Bakhsh
Breast Cancer Research group, Iranian Academic Center for Education, Culture and Research, Tehran, Iran
Parvin Pasalar
Department of Biochemistry, Tehran University of Medical Sciences, Tehran, Iran
Ali Aminian
Bariatric and Metabolic Institute, Cleveland Clinic, Cleveland, Ohio, US
aminiaa@ccf.org (##journal.primary_contact##)
1.
Elyasinia F, Chegini V, Olfat-Bakhsh A, Pasalar P, Aminian A. Superoxide Dismutase Activities in Plasma of Patients with Breast Cancer. Arch Breast Cancer [Internet]. 31 août 2014 [cité 12 janv. 2026];1(2):69-72. Disponible à: https://archbreastcancer.com/index.php/abc/article/view/6
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(c) Tous droits réservés Fezzeh Elyasinia, Venus Chegini, Asieh Olfat-Bakhsh, Parvin Pasalar, Ali Aminian 2014

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Cette œuvre est sous licence Creative Commons Attribution - Pas d'Utilisation Commerciale 4.0 International.

Copyright©. This is an open-access article distributed under the terms of the Creative Commons Attribution-Non-Commercial 4.0 International License, which permits copy and redistribution of the material in any medium or format or adapt, remix, transform, and build upon the material for any purpose, except for commercial purposes.

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