Superoxide Dismutase Activities in Plasma of Patients with Breast Cancer

Fezzeh Elyasinia (1), Venus Chegini (2), Asieh Olfat-Bakhsh (3), Parvin Pasalar (4), Ali Aminian (5)
(1) Department of Surgery, Tehran University of Medical Sciences, Tehran, Iran,
(2) Department of Gynecology and Obstetrics, Tehran University of Medical Sciences, Tehran, Iran,
(3) Breast Cancer Research group, Iranian Academic Center for Education, Culture and Research, Tehran, Iran,
(4) Department of Biochemistry, Tehran University of Medical Sciences, Tehran, Iran,
(5) Bariatric and Metabolic Institute, Cleveland Clinic, Cleveland, Ohio, US

Abstract

Background: Superoxide radicals are produced during oxidative metabolic processes, and removed by superoxide dismutase (SOD) enzymes. Controversial results have been reported regarding the tissue and plasma concentration of SOD in patients with breast cancer.

Methods: Venous blood was obtained from study participants and activity of SOD enzyme was determined in 100 women. Comparison was made between 50 patients with breast cancer and 50 individuals in control group.

Results: The activities of SOD in patients with malignancy and control group were 553.56±53.67 U/gr Hb and 1218.60±98.55 U/gr Hb, respectively (P <0.001). Patients with higher stage and nuclear grade had lower SOD activity.

Conclusions: lower levels of SOD activity was observed in women with breast cancer compared to healthy individuals. Considering the existing controversy regarding the SOD level in breast cancer patients, further studies to explore the reason of these differences are warranted.

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Authors

Fezzeh Elyasinia
Venus Chegini
Asieh Olfat-Bakhsh
Parvin Pasalar
Ali Aminian
aminiaa@ccf.org (Primary Contact)
1.
Elyasinia F, Chegini V, Olfat-Bakhsh A, Pasalar P, Aminian A. Superoxide Dismutase Activities in Plasma of Patients with Breast Cancer. Arch Breast Cancer [Internet]. 2014 Aug. 31 [cited 2024 Apr. 13];1(2):69-72. Available from: https://archbreastcancer.com/index.php/abc/article/view/6

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