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Lobular Carcinoma, Breast Cancer, Skin Metastasis, Stomach Metastasis, Immunohistochemistry
Background: Skin metastases occur in 1-5% of solid tumors and are rarely the presenting sign of internal malignancies. Certain features in skin lesions raise suspicion of metastasis from solid tumors.
Case Presentation: In this article a 61-year-old woman is presented with erythematous skin nodules in upper abdomen and chest. Histopathological evaluation of lesions suggested metastatic carcinoma and a thorough search found stomach signet cell adenocarcinoma and breast lobular carcinoma. Immunohistochemical staining confirmed diagnosis of lobular carcinoma with metastasis developed in skin and stomach.
Conclusions: Clinicians must be aware that malignancies can present by skin metastases. Since breast and stomach cancer can both metastasize to skin, immunohistochemistry evaluation is of great importance to diagnose the primary tumor.