Trace Elements Homeostasis in Biological Samples as New Candidate Biomarkers for Early Diagnosis and Prognostic of Female Breast Cancer and Therapeutic Response: Systematic Review Biomarkers for Early Diagnosis of Breast Cancer
Main Article Content
Keywords
Breast cancer, Circulating trace elements, Predictive biomarker, Patient survival, Biological homeostasis.
Abstract
Background: Female breast cancer (BC) remains the most common cause of total cancer deaths around the world. Several studies have investigated BC biomarkers, but vital circulating biomarkers for early diagnosis of malignancy are still scarce. Thus, finding sensitive, selective and accurate biomarkers is required to get better BC outcome and to prolong patients’ survival. Therefore, this review investigated the feasibility of using circulating trace elements (TEs) as the new promising biological biomarkers for BC diagnosis and prevention.
Methods: We systematically searched EMBASE, Medline, Google Scholar, PubMed, SciELO, Scopus databases or Web of Science for orginal studies presenting the significant changes in the concentrations of circulating TEs in terms of serum, plasma or blood from female breast cancer patients.
Results: The search yielded 2697 articles, of which 39 were considered for this review. The study showed that four essential TEs (Se, Cu, Zn and Mn) significantly decreased when only one essential trace elemnt (Fe) increased consistently, while five toxics circulating TEs (Cd, Cr, Pb, Co, Mo) increased significantly with a significant difference compared to healthy groups. The essential TEs, Se and Cu were reported to decrease the most in fifteen and twenty-one studies, respectively. However, regarding the toxic circulating TEs, Cd and Pb were found to increase most significantly in seven studies. Among the essential TEs, Se and Zn were reported to have the most potential, with Cd and Pb having the most potential for use as new promising biomarkers to diagnose or prevent BC.
Conclusion: The findings provide an insight into the TEs circulating biomarkers for early BC diagnosis and prevention. Due to its high heterogeneity, meta-analysis was not assessed; hence, futher investigation may be required on their clinical outcomes in BC with high sensitivity and specificity for accurate therapeutic response.
References
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9. Panchal H, Matros E. Current Trends in Post-Mastectomy Breast Reconstruction. Plast Reconstr Surg. 2017; 140(5): 7S–13S. doi:10.1097/PRS.0000000000003941
10. Brewster AM, Hortobagyi GN, Broglio KR, Kau SW, Santa-Maria CA, Arun B, et al. Residual risk of breast cancer recurrence 5 years after adjuvant therapy. J Natl Cancer Inst. 2008; 100(16):1179-183. doi: 10.1093/jnci/djn233
11. Freedman GM, Fowble BL. Local recurrence after mastectomy or breast-conserving surgery and radiation. Oncology (Williston Park). 2000; 14(11):1561-1581; discussion 1581-1562, 1582-1564.
12. Torre LA, Bray F, Siegel RL, Ferlay J, Lortet-Tieulent J, Jemal A. Global cancer statistics, 2012. CA Cancer J Clin. 2015;65(2):87-108. doi:10.3322/caac.21262
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15. Moran MS, Truong PT. Hypofractionated radiation treatment of breast cancer: The time is now. Breast J. 2020;00:1–8. doi: 10.1111/tbj.13724
16. Gupta A, Ohiri N, Haffty BG. Hypofractionated radiation treatment in the management of breast cancer. Expert Rev Anticancer Ther. 2018; 18(8): 793–803. doi:10.1080/14737140.2018.1489245
17. Pondè NF, Zarvadas D, Piccart M. Progress in adjuvant systemic therapy for breast cancer- Nat Rev Clin Oncol. 2019 Jan; 16(1):27-44. doi: 10.1038/s41571-018-0089-9
18. Syed YY. Oncotype DX Breast Recurrence Score ®: A Review of its Use in Early-Stage Breast Cancer. Mol Diagn Ther. 2020 Oct;24(5):621-632. doi: 10.1007/s40291-020-00482-7
19. Almstedt K, Mendoza S, Otto M, Battista MJ, Steetskamp J, Heimes AS, et al. EndoPredict® in early hormone receptor-positive, HER2-negative breast cancer. Breast Cancer Res Treat. 2020 Jul;182(1):137-146. doi: 10.1007/s10549-020-05688-1
20. Recht A, Come SE, Henderson IC, Gelman RS, Silver B, Hayes DF, et al. The sequencing of chemotherapy and radiation therapy after conservative surgery for early stage breast cancer. N Engl J Med .1996; 334:1356- 61, doi: 10.1056/NEJM199605233342102
21. Bellon JR, Come SE, Gelman RS, Henderson IC, Shulman LN, Silver BJ, et al. Sequencing of chemotherapy and radiation therapy in early-stage breast cancer: updated results of a prospective randomized trial. J Clin Oncol. 2005 Mar 20;23(9):1934-40. doi: 10.1200/JCO.2005.04.032
22. Belletti B, Vaidya JS, D'Andrea S, Entschladen F, Roncadin M, Lovat F, et al. Targeted intraoperative radiotherapy impairs the stimulation of breast cancer cell proliferation and invasion caused by surgical wounding. Clin Cancer Res. 2008 Mar 1;14(5):1325-32. doi: 10.1158/1078-0432.CCR-07-4453.
23. Formenti SC, Demaria S. Local control by radiotherapy: is that all there is? Breast Cancer Research 2008, 10:215-22. doi:10.1186/bcr2160.
24. Fisher B, Gunduz N, Coyle J, Rudock C, Saffer E. Presence of a growth-stimulating factor in serum following primary tumor removal in mice. Cancer Res 1989; 49: 1996–2001
25. Cortazar P, Zhang L, Untch M, Mehta K, Costantino JP, Wolmark N, et al. Pathological complete response and long-term clinical benefit in breast cancer: the CTNeoBC pooled analysis. Lancet 2014; 384: 164–72. doi: 10.1016/S0140-6736(13)62422-8
26. von Minckwitz G, Blohmer JU, Costa SD, Denkert C, Eidtmann H, Eiermann W, et al. Response-guided neoadjuvant chemotherapy for breast cancer. J Clin Oncol 2013; 31: 3623–30. doi: 10.1200/JCO.2012.45.0940.
27. Cortazar P, Geyer CE jr. Pathological complete response in neaoadjuvant treatment of breast cancer. Ann Surg Oncol. 2015 May;22(5):1441-6. doi: 10.1245/s10434-015-4404-8
28. Houssami N, Macaskill P, von Minckwitz G, Marinovich ML, Mamounas E. Meta-analysis of the association of breast cancer subtype and pathologic complete response to neoadjuvant chemotherapy. Eur J Cancer. 2012; 48(18): 3342–54. doi: 10.1016/j.ejca.2012.05.023
29. Denkert C, Liedtke C, Tutt A, von Minckwitz G. Molecular alterations in triple-negative breast cancer-the road to new treatment strategies. Lancet. 2017 Jun 17;389(10087):2430–42. doi: 10.1016/S0140-6736(16)32454-0.
30. McGuire SE, Gonzalez-Angulo AM, Huang EH, Tucker SL, Kau SW, Yu TK, et al. Postmastectomy radiation improves the outcome of patients with locally advanced breast cancer who achieve a pathologic complete response to neoadjuvant chemotherapy. Int J Radiat Oncol Biol Phys. 2007 Jul 15;68(4):1004-9. doi: 10.1016/j.ijrobp.2007.01.023.
31. Mamounas EP, Bandos H, White JR, Julian TB, Khan AJ, Shaitelman SF, et al. NRG Oncology/NSABP B-51/RTOG 1304: Phase III trial to determine if chest wall and regional nodal radiotherapy (CWRNRT) post mastectomy (Mx) or the addition of RNRT to whole breast RT post breast-conserving surgery (BCS) reduces invasive breast cancer recurrence-free interval (IBCR-FI) in patients (pts) with pathologically positive axillary (PPAx) nodes who are ypN0 after neoadjuvant chemotherapy (NC). Journal of Clinical Oncology 2019. doi: 10.1200/JCO.2019.37.15_suppl.TPS600.
32. Boughey J, Haffty B, Buchholz T, Symmans WF, Hunt K, Armer J, et al. Alliance A011202: A Randomized Phase III Trial Comparing Axillary Lymph Node Dissection to Axillary Radiation in Breast Cancer Patients (cT1-3 N1) Who Have Positive Sentinel Lymph Node Disease After Receiving Neoadjuvant Chemotherapy. Available from: https://www.allianceforclinicaltrialsinoncology.org/main/cmsfile?cmsPath=/Public/Annual%20Meeting/files/A011202-Boughey-May2019.pdf
33. Mandish S, Gaskins JT, Yusuf MB, Amer YM, Eldredge-Hindy H. The effect of omission of adjuvant radiotherapy after neoadjuvant chemotherapy and breast conserving surgery with a pathologic complete response. Acta Oncol 2020; 59(10): 1210-17. doi: 10.1080/0284186X.2020.1797161
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Laya A, Wangso H, Camargo JM, Siewe FB, Rashmi HB, Mathew NS, Henrique Destro P, Medeiros Junior G, Koubala B, Bueno V. Trace Elements Homeostasis in Biological Samples as New Candidate Biomarkers for Early Diagnosis and Prognostic of Female Breast Cancer and Therapeutic Response: Systematic Review : Biomarkers for Early Diagnosis of Breast Cancer. Arch Breast Cancer [Internet]. 2022 Nov. 14 [cited 2023 Mar. 30];10(1):26-37. Available from: https://archbreastcancer.com/index.php/abc/article/view/635
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Author Biographies
Honoré Wangso, Department of Chemistry, Faculty of Science, University of Maroua, P.O. Box 814 Maroua, Cameroon
2Department of Chemistry, Faculty of Science, University of Maroua, P.O. Box 814 Maroua, Cameroon
Joyce Moreira Camargo, Department of Microbiology, Parasitology and Immunology, UNIFESP Federal University of São Paulo, Brazil
5Department of Microbiology, Parasitology and Immunology, UNIFESP Federal University of São Paulo, Brazil
Havalli Bommegowda Rashmi, Fruit and Vegetable Technology Department, CSIR-Central Food Technological Research Institute, Mysore, India.
Fruit and Vegetable Technology Department, CSIR-Central Food Technological Research Institute, Mysore, India.
Pedro Henrique Destro, Department of Biomedicine, UNIFESP Federal University of São Paulo, Brazil
Department of Biomedicine, UNIFESP Federal University of São Paulo, Brazil
Geraldo Medeiros Junior, Department of Biomedicine, UNIFESP Federal University of São Paulo, Brazil.
Department of Biomedicine, UNIFESP Federal University of São Paulo, Brazil.
Benoît Koubala, Department of Chemistry, Faculty of Science, University of Maroua, P.O. Box 814 Maroua, Cameroon
Department of Chemistry, Faculty of Science, University of Maroua, P.O. Box 814 Maroua, Cameroon
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