Study Protocol to Quantify Breast-Chest Wall Motion in Free Breathing, Version 5.1 Study protocol

Vincent Vinh-Hung (1), Fatemeh Jafari (2), Mark De Ridder (3)
(1) Institut Bergonié, France,
(2) Department of Radiation Oncology, Tehran University of Medical Sciences, Tehran, Iran, Iran, Islamic Republic of,
(3) Department of Radiotherapy Oncology, Institut Bergonié, Bordeaux, France., France
https://doi.org/10.32768/abc.2023104388-393

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Issue
Volume 10, Issue 4, November 2023
Submitted
October 17, 2023
Published
October 31, 2023
Keywords:
    Study protocol, chest wall motion, Radiotherapy
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Abstract

Background: Four-dimensional computed tomography (4D-CT) acquires multiple CT images over time, allowing to visualize the respiratory motion of organs and tumors. In patients undergoing 4D-CT for stereotactic radiotherapy of intra-thoracic tumors, 4D-CT provides the opportunity to study the incidental movements of the breast during normal breathing. A study protocol to investigate breast respiratory motion is presented herein.


Methods: Patients with any primary cancer who underwent 4D-CT will be retrospectively selected from a radiotherapy treatment planning database. Study inclusion requires full lungs and breasts coverage in the 4D-CT images. Patients with advanced tumors are excluded. The protocol details breast locations of interest (upper, lower, inner, outer, central), specifies virtual breast tumor beds, and details how breast motion will be measured. Data will be analyzed to quantify the range of movements, to evaluate breast motion according to laterality and location, and to evaluate the correlation between movements of the breast and the intra-thoracic organs.


Results: Results should provide quantitative information on the extent of breast movements during free breathing, which could be valuable to plan for respiratory control during breast radiotherapy.


Conclusion: The study is retrospective, but the design of data acquisition is prospective, to mitigate recollection bias and enhance reproducibility.

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Authors

Vincent Vinh-Hung
Institut Bergonié
anhxang@gmail.com (Primary Contact)
Fatemeh Jafari
Department of Radiation Oncology, Tehran University of Medical Sciences, Tehran, Iran
Mark De Ridder
Department of Radiotherapy Oncology, Institut Bergonié, Bordeaux, France.
1.
Vinh-Hung V, Jafari F, De Ridder M. Study Protocol to Quantify Breast-Chest Wall Motion in Free Breathing, Version 5.1: Study protocol. Arch Breast Cancer [Internet]. 2023 Oct. 31 [cited 2024 Jul. 16];10(4):388-93. Available from: https://archbreastcancer.com/index.php/abc/article/view/822
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