Study Protocol to Quantify Breast-Chest Wall Motion in Free Breathing, Version 5.1 Study protocol

Vincent Vinh-Hung (1), Fatemeh Jafari (2), Mark De Ridder (3)
(1) Institut Bergonié, France,
(2) Department of Radiation Oncology, Tehran University of Medical Sciences, Tehran, Iran, Iran, Islamic Republic of,
(3) Department of Radiotherapy Oncology, Institut Bergonié, Bordeaux, France., France
https://doi.org/10.32768/abc.2023104388-393

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Issue
Volume 10, Issue 4, November 2023
Submitted
October 17, 2023
Published
October 31, 2023
Keywords:
    Study protocol, chest wall motion, Radiotherapy
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Abstract

Background: Four-dimensional computed tomography (4D-CT) acquires multiple CT images over time, allowing to visualize the respiratory motion of organs and tumors. In patients undergoing 4D-CT for stereotactic radiotherapy of intra-thoracic tumors, 4D-CT provides the opportunity to study the incidental movements of the breast during normal breathing. A study protocol to investigate breast respiratory motion is presented herein.


Methods: Patients with any primary cancer who underwent 4D-CT will be retrospectively selected from a radiotherapy treatment planning database. Study inclusion requires full lungs and breasts coverage in the 4D-CT images. Patients with advanced tumors are excluded. The protocol details breast locations of interest (upper, lower, inner, outer, central), specifies virtual breast tumor beds, and details how breast motion will be measured. Data will be analyzed to quantify the range of movements, to evaluate breast motion according to laterality and location, and to evaluate the correlation between movements of the breast and the intra-thoracic organs.


Results: Results should provide quantitative information on the extent of breast movements during free breathing, which could be valuable to plan for respiratory control during breast radiotherapy.


Conclusion: The study is retrospective, but the design of data acquisition is prospective, to mitigate recollection bias and enhance reproducibility.

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References

Early Breast Cancer Trialists' Collaborative G. Effects of radiotherapy and of differences in the extent of surgery for early breast cancer on local recurrence and 15-year survival: an overview of the randomised trials. Lancet 2005; 366: 2087-2106. doi: 10.1016/S0140-6736(05)66544-0.

Van de Steene J, Soete G and Storme G. Adjuvant radiotherapy for breast cancer significantly improves overall survival: the missing link. Radiother Oncol 2000; 55: 263-272. doi: 10.1016/s0167-8140(00)00204-8.

Taylor CW, Nisbet A, McGale P and Darby SC. Cardiac exposures in breast cancer radiotherapy: 1950s-1990s. Int J Radiat Oncol Biol Phys 2007; 69: 1484-1495. doi: 10.1016/j.ijrobp.2007.05.034.

Van de Steene J, Vinh-Hung V, Cutuli B and Storme G. Adjuvant radiotherapy for breast cancer: effects of longer follow-up. Radiother Oncol 2004; 72: 35-43. doi: 10.1016/j.radonc.2004.04.004.

Pignol JP, Olivotto I, Rakovitch E, Gardner S, Sixel K, Beckham W, et al. A multicenter randomized trial of breast intensity-modulated radiation therapy to reduce acute radiation dermatitis. J Clin Oncol 2008; 26: 2085-2092. doi: 10.1200/JCO.2007.15.2488.

Keall PJ, Mageras GS, Balter JM, Emery RS, Forster KM, Jiang SB, et al. The management of respiratory motion in radiation oncology report of AAPM Task Group 76. Med Phys 2006; 33: 3874-3900. doi: 10.1118/1.2349696.

Offersen BV, Boersma LJ, Kirkove C, Hol S, Aznar MC, Biete Sola A, et al. ESTRO consensus guideline on target volume delineation for elective radiation therapy of early stage breast cancer. Radiother Oncol 2015; 114: 3-10. doi: 10.1016/j.radonc.2014.11.030.

O'Brien K and Wright J. How to write a protocol. J Orthod 2002; 29: 58-61. doi: 10.1093/ortho/29.1.58.

Al Shakarchi J. How to write a research study protocol. Journal of Surgical Protocols and Research Methodologies 2022; 2022. doi: 10.1093/jsprm/snab008.

Al-Jundi A and Sakka S. Protocol Writing in Clinical Research. J Clin Diagn Res 2016; 10: ZE10-ZE13. 20161101. doi: 10.7860/JCDR/2016/21426.8865.

Cameli M, Novo G, Tusa M, Mandoli GE, Corrado G, Benedetto F, et al. How to Write a Research Protocol: Tips and Tricks. J Cardiovasc Echogr 2018; 28: 151-153. doi: 10.4103/jcecho.jcecho_41_18.

Chan AW, Tetzlaff JM, Gøtzsche PC, Altman DG, Mann H, Berlin JA, et al. SPIRIT 2013 explanation and elaboration: guidance for protocols of clinical trials. BMJ 2013; 346: e7586. 20130108. doi: 10.1136/bmj.e7586.

Feng M, Moran JM, Koelling T, Chughtai A, Chan JL, Freedman L, et al. Development and validation of a heart atlas to study cardiac exposure to radiation following treatment for breast cancer. Int J Radiat Oncol Biol Phys 2011; 79: 10-18. doi: 10.1016/j.ijrobp.2009.10.058.

Authors

Vincent Vinh-Hung
Institut Bergonié
anhxang@gmail.com (Primary Contact)
Fatemeh Jafari
Department of Radiation Oncology, Tehran University of Medical Sciences, Tehran, Iran
Mark De Ridder
Department of Radiotherapy Oncology, Institut Bergonié, Bordeaux, France.
1.
Vinh-Hung V, Jafari F, De Ridder M. Study Protocol to Quantify Breast-Chest Wall Motion in Free Breathing, Version 5.1: Study protocol. Arch Breast Cancer [Internet]. 2023 Oct. 31 [cited 2025 Mar. 10];10(4):388-93. Available from: https://archbreastcancer.com/index.php/abc/article/view/822
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