Breast Pilomatrixoma in a 47-year-old Woman: Pathological and Radiological Diagnosis Breast Pilomatrixoma

Shokouh Taghipour Zahir (1), Fatemeh Derakhshani (2), Koorosh Rahmani (3), Seyed Mostafa Shiryazdi (4)
(1) Department of Pathology, Shahid Sadoughi University of Medical sciences and Health Services,Yazd, Iran , Iran, Islamic Republic of,
(2) Department of Pathology, Shahid Sadoughi University of Medical sciences and Health Services,Yazd, Iran, Iran, Islamic Republic of,
(3) General Practitioner, Shahid Sadoughi University of Medical sciences and Health Services,Yazd, Iran , Iran, Islamic Republic of,
(4) Department of surgery, Shahid Sadoughi University of Medical sciences and Health Services,Yazd, Iran , Iran, Islamic Republic of


Background: Pilomatrixoma   is a benign adnexal tumor with differentiation towards the matrix of the hair follicle and occurs mostly in the head, neck, and upper extremities of the child. Pilomatrixoma of the breast is considered a very rare tumor.

Case presentation: Herein, we present a 47-year-old woman who was referred to the surgery ward for a palpable right breast mass. Imaging studies revealed a well-circumscribed lesion categorized as BIRADs3. Because clinically the lesion was large and had a stony hard consistency so patient underwent surgery and intraoperative consultation was negative and revealed a well-defined lesion composed of basaloid cells, multinucleated giant cells admixed with bone trabeculae, and nests of ghost cells. Immunohistochemical (IHC) studies were done and the cells were positive for AE1/AE3, Beta-catenin, and BCL2 and negative for Mart1 and CD117. Based on H&E and IHC studies, pilomatrixoma of the breast tissue was confirmed.

Conclusion: Breast pilomatrixoma   is a very rare benign neoplasm that could clinically mimic malignant neoplasm and should be considered in the differential diagnosis of breast masses

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Tokur O, Aydin S, Seher Oztekin P, Suleyman M, Erel S, Celepli P. Pilomatrixoma of the breast in a male patient. lmaging lnterv. 2021;1(2):44-46. doi: 10.5152/ iai.2021.21034.

Borders MH, Fitzpatrick KA, McClenathan JH. Benign pilomatrixoma of the breast. Appl Radiol. 2012;1(1):1.

Agrawal R, Kumar P. Pilomatrixoma - unveiling the ghost story: Report of 5 cases with review of the literature. Int J Case Rep Images 2015;6(4):193-197. doi: 10.5348/ijcri-201502-CS-10053.

Pai T, Harwani SR, Patil A, Sahay A, Shet T, Parmar V, Wadasadawala T, Desai SB. Pilomatrix Carcinoma Masquerading as Breast Carcinoma. Indian J Med Paediatr Oncol. 2017 Jul- Sep;38(3):367-370. doi: 10.4103/ijmpo.ijmpo-118-16. PMID: 29200693; PMCID: PMC5686986.

Kapoor A, Narayanan R, Tandon A, Santosh AK. Pilomatrixoma : An unusual cause of lump in a male breast. J Clin Ultrasound. 2018 Mar;46(3):209-211. doi: 10.1002/jcu.22503. Epub 2017 May 29. PMID: 28555882.

Gil JR, Herh SJ, Kim Y, Song MA, Kim MY, Kim E. A pilomatrixoma misdiagnosed as male breast cancer. J Korean Soc Radiol. 2016 Mar;74(3):156-159. doi: 10.3348/jksr.2016.74.3.156.

Sood N, Raj B. Pilomatrixoma male breast, mimicking breast carcinoma-A rare case. Indian J Pathol Microbiol. 2021 Jan-Mar;64(1):204-205. doi: 10.4103/IJPM.IJPM_194_20. PMID: 33433446.

Clark A, Leddy R, Spruill L, Cluver A. Pilomatrixoma , a Rare Mimicker of Male Breast Cancer. J Clin Imaging Sci. 2019 Nov 6;9:46. doi: 10.25259/JCIS_64_2019. PMID: 31819823; PMCID: PMC6884983.

Fonseca RPL, Andrad FilhoJS, Araujo IC, Silva Filho AF, Pereira NA, Carvalho EES, et al. Pilomatrixoma : calcifying epithelioma of Malherbe. Rev. Bras. Cir. Plast.2012;27(4):605-610.

Nori J, Abdulcadir D, Giannotti E, Calabrese M. Pilomatrixoma of the breast, a rare lesion simulating breast cancer: a case report. J Radiol Case Rep. 2013 Oct 1;7(10):43-50. doi: 10.3941/jrcr.v7i10.1651. PMID: 24421922; PMCID: PMC3888343.

Hubeny CM, Sykes JB, O'Connell A, Dogra VS. Pilomatrixoma of the adult male breast: a rare tumor with typical ultrasound features. J Clin Imaging Sci. 2011;1:12. doi: 10.4103/2156-7514.76690. Epub 2011 Feb 11. PMID: 21977385; PMCID: PMC3173833.

Rachakonda T, Kacker A, Koizumi J. Pediatric pilomatrixoma of the preauricular region. Acta Cytol. 2010 Sep-Oct;54(5):724-6. doi: 10.1159/000325241. PMID: 20968163.

Mitteldorf CATDS, Vilela RS, Fugimori ML, de Godoy CD, Coudry RA. Novel Mutations in Pilomatrixoma , CTNNB1 p.s45F, and FGFR2 p.s252L: A Report of Three Cases Diagnosed by Fine-Needle Aspiration Biopsy, with Review of the Literature. Case Rep Genet. 2020 Aug 29;2020:8831006. doi: 10.1155/2020/8831006. PMID: 32908727; PMCID: PMC7475758.

Martins M, Lucarelli A, Aldrighi J, Forattini A. A case report of calcifying epithelioma of Malherbe (pilomatrixoma ) mimicking breast carcinoma in male patient. Case reports in clinical medicine. 2014;3:276-180. doi: 10.4236/crcm.2014.35063.

Lozzi GP, Soyer HP, Fruehauf J, Massone C, Kerl H, Peris K. Giant pilomatrixoma . Am J Dermatopathol. 2007 Jun;29(3):286-9. doi: 10.1097/DAD.0b013e318053db45. PMID: 17519628.17.

Bhuta R, Wring G, Lau Q, Bhuta S. Metastatic malignant pilomatrixoma : a case report and review of the literature.Pathology. 2009 Jan;41(1):1-87. doi: 10.1097/01268031-200941001-00124.

Malgras B, Durand X, Camparo P, Houlgatte A. Pilomatricome scrotal : à propos d'un cas et revue de la littérature [Scrotal pilomatrixoma : a case report and review of the literature]. Prog Urol. 2010 Jun;20(6):469-71. French. doi: 10.1016/j.purol.2009.10.007. PMID: 20538214.

Hamilton A, Young GI, Davis RI. Pilomatrixoma mimicking breast carcinoma. Br J Dermatol. 1987 Apr;116(4):585-6. doi: 10.1111/j.1365-2133.1987.tb05883.x. PMID: 3580292.


Shokouh Taghipour Zahir
Fatemeh Derakhshani (Primary Contact)
Koorosh Rahmani
Seyed Mostafa Shiryazdi
Taghipour Zahir S, Derakhshani F, Rahmani K, Shiryazdi SM. Breast Pilomatrixoma in a 47-year-old Woman: Pathological and Radiological Diagnosis: Breast Pilomatrixoma. Arch Breast Cancer [Internet]. [cited 2024 Feb. 22];11(2). Available from:

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