PERSPECTIVE; Systemic Therapy After Curative Local Treatment for Isolated Locoregional Recurrence in Triple-Negative Breast Cancer: Evidence Gaps and a Practical Clinical Framework
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References
Wapnir IL, Price KN, Anderson SJ, et al. Efficacy of Chemotherapy for ER-Negative and ER-Positive Isolated Locoregional Recurrence of Breast Cancer: Final Analysis of the CALOR Trial. J Clin Oncol. Apr 10 2018;36(11):1073-1079. doi:10.1200/JCO.2017.76.5719
Ferrari P, Scatena C, Ghilli M, Bargagna I, Lorenzini G, Nicolini A. Molecular Mechanisms, Biomarkers and Emerging Therapies for Chemotherapy Resistant TNBC. Int J Mol Sci. Jan 31 2022;23(3). doi:10.3390/ijms23031665
Lluch A, Barrios CH, Torrecillas L, et al. Phase III Trial of Adjuvant Capecitabine After Standard Neo-/Adjuvant Chemotherapy in Patients With Early Triple-Negative Breast Cancer (GEICAM/2003-11_CIBOMA/2004-01). J Clin Oncol. Jan 20 2020;38(3):203-213. doi:10.1200/JCO.19.00904
Mayer IA, Zhao F, Arteaga CL, et al. Randomized Phase III Postoperative Trial of Platinum-Based Chemotherapy Versus Capecitabine in Patients With Residual Triple-Negative Breast Cancer Following Neoadjuvant Chemotherapy: ECOG-ACRIN EA1131. J Clin Oncol. Aug 10 2021;39(23):2539-2551. doi:10.1200/JCO.21.00976
Tutt ANJ, Garber JE, Kaufman B, et al. Adjuvant Olaparib for Patients with BRCA1- or BRCA2-Mutated Breast Cancer. N Engl J Med. Jun 24 2021;384(25):2394-2405. doi:10.1056/NEJMoa2105215
Schmid P, Cortes J, Pusztai L, et al. Pembrolizumab for Early Triple-Negative Breast Cancer. N Engl J Med. Feb 27 2020;382(9):810-821. doi:10.1056/NEJMoa1901917
Ignatiadis M, Bailey A, McArthur H, et al. Adjuvant Atezolizumab for Early Triple-Negative Breast Cancer: The ALEXANDRA/IMpassion030 Randomized Clinical Trial. Jama. Jan 30 2025;333(13):1150-1160. doi:10.1001/jama.2024.26886
Nader-Marta G, Monteforte M, Agostinetto E, et al. Circulating tumor DNA for predicting recurrence in patients with operable breast cancer: a systematic review and meta-analysis. ESMO Open. Mar 2024;9(3):102390. doi:10.1016/j.esmoop.2024.102390
Zhang D, Jahanfar S, Rabinowitz JB, et al. Role of circulating tumor DNA in early-stage triple-negative breast cancer: a systematic review and meta-analysis. Breast Cancer Res. Mar 12 2025;27(1):38. doi: 10.1186/s13058-025-01986-y
Xu J, Fang K, Li X, Han L, Sun S, Sun T. From residual risk to precision intervention: the evolving role of minimal residual disease in breast cancer management. Cancer Biol Med. Nov 28 2025;22(12):1493-1514. doi: 10.20892/j.issn.2095-3941.2025.0431
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