Association of Lipid Profile Markers with Breast Cancer: An Analysis of the KFSH Study in Dammam, KSA Lipid profile markers in BC
Abstract
Background: Breast cancer (BC) is a heterogeneous disease characterized by the presence of a lump or mass in the lymph nodes of the breast. BC has not only been associated with an abnormal lipid profile but also with hypertriglyceridemia, high-density lipoproteins (HDLs), low-density lipoproteins (LDLs), and triglycerides (TG). Its relationship with increased levels of serum lipids is controversial. This study investigated the association of circulating lipid profiles with BC among Saudi women and provides further insight into the interplay of age in these patients.
Methods: Three hundred and ninety-nine (399) women between the years 2018 and 2021 were selected for this case control study based on the presence (for cases) or absence (for controls) of BC at the King Fahd specialist hospital-Dammam (KFSH-D). This study was approved by the human research ethics committees at King Fahad Specialist Hospital-Dammam (LAB0318). The lipid levels of women with BC were compared to the lipid levels of women with benign breast disease and healthy women. Data on total cholesterol, HDL, LDL, and TG were collected from 200 BC diagnosed patients and 199 healthy individuals. Statistical analysis was performed using the t-test.
Results: This study shows significant differences between BC and controls in terms of total cholesterol, HDL, and TG, and insignificant differences in LDL levels.
Conclusion: This study revealed a strong association between the circulating lipid profile and breast cancer.
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References
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