Number of Sentinel Lymph Nodes Removed in Breast Cancer Patients – A Real-World Experience

Tyrell Wees; Kehkashan Qureshi; Gopinath Narasimhan; Shahid Ahmed; Ambika Chandrasekhar; Osama Souied; Osama Ahmed; Shazia Mahmood; Ayesha Bashir; Muhammad Khan; Habib Khan; Haji Chalchal

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Tyrell Wees ⁽¹⁾, Kehkashan Qureshi ⁽²⁾, Gopinath Narasimhan ⁽³⁾, Shahid Ahmed ⁽⁴⁾, Ambika Chandrasekhar ⁽⁵⁾, Osama Souied ⁽⁶⁾, Osama Ahmed ⁽⁷⁾, Shazia Mahmood ⁽⁸⁾, Ayesha Bashir ⁽⁹⁾, Muhammad Khan ⁽¹⁰⁾, Habib Khan ⁽¹¹⁾, Haji Chalchal ⁽¹²⁾

(1) College of Medicine, University of Alberta, Edmonton, Canada, Canada,

(2) College of Medicine, University of Saskatchewan, Saskatoon, Canada, Canada,

(3) Saskatchewan Cancer Agency, Regina, Saskatoon, Canada, Canada,

(4) College of Medicine, University of Saskatchewan, Saskatoon, Canada, Canada,

(5) Saskatchewan Cancer Agency, Regina, Saskatoon, Canada, Canada,

(6) College of Medicine, University of Saskatchewan, Saskatoon, Canada, Canada,

(7) College of Medicine, University of Saskatchewan, Saskatoon, Canada, Canada,

(8) College of Medicine, University of Saskatchewan, Saskatoon, Canada, Canada,

(9) College of Medicine, University of Saskatchewan, Saskatoon, Canada, Canada,

(10) College of Medicine, University of Saskatchewan, Saskatoon, Canada, Canada,

(11) College of Medicine, University of Saskatchewan, Saskatoon, Canada, Canada,

(12) College of Medicine, University of Saskatchewan, Saskatoon, Canada, Canada

Issue
Vol. 12 No. 2 (2025): In-Press for May 2025

Keywords:

sentinel lymph node biopsy, breast neoplasms, disease-free survival, body mass index, lymph node excision, lymphedema

No galleys available

Abstract

Background: Retrieval of less than three Sentinel lymph nodes (SLN) has been shown to be associated with decrease disease specific survival. We aimed to find if the real-world experience replicates the data.

Methods: 529 patients with breast cancer (BC) who underwent sentinel lymph node biopsy (SLNB) from Jan 2010 to Dec 2014 were retrospectively reviewed. Data was analyzed using SAS 9.4 software. Chi square test was used if body mass index (BMI) influences the number of SLN retrieved and to detect difference between the variables of using blue dye and radioisotopes for detecting SLN.

Results: Proportion of one, two and three or more SLN retrieval was 21, 35 and 44% respectively with the median number two. There was no difference in the number of lymph nodes retrieved if the radioisotope (RI) was used alone or in combination with blue dye (BD). P value of 0. 88. No change in median number of SLN retrieved in different quadrants of the breast was noted. We obtained body mass index (BMI) in 454 patients. The rate of more than two SLN retrieval in patients with normal BMI was 16%. In overweight 12% and obese 18%. We compared SLN= (one, two) vs. SLN= two + group which are crossed tabbed against three BMI categories of normal, overweight and obese. This was statistically significant, p-value of 0. 028.

Conclusion: The real-world data suggest sub-optimal retrieval of number of median SLN compared to clinical trials. Higher BMI was associated with less than three SLN retrieved.

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Authors

Tyrell Wees

College of Medicine, University of Alberta, Edmonton, Canada

https://orcid.org/0000-0002-8977-949X

Kehkashan Qureshi