The Impact of Soy Isoflavone Intake on Mammographic Density: A Systematic Review and Meta-analysis Isoflavone & mammographic density
Abstract
Background: It is suggested that the comparatively elevated consumption of soy in Asian countries may contribute to the decreased incidence of breast cancer observed in these regions when compared to the Western world. The objective of this meta-analysis study was to investigate the impact of daily soy supplementation on mammographic density, which is recognized as one of the most influential risk factors for breast cancer.
Methods: PubMed, Scopus, and Web of Science were queried until May 2024. We extracted publications that met our specific eligibility criteria to obtain data on fractional anisotropy and brain connectivity. The digital data was extracted using the WebPlotDigitizer. We utilized the most recent iteration of Stata (version 18) to perform a meta-analysis on the data. The quality evaluation of the studies was conducted utilizing a critical appraisal instrument.
Results: The results of the analysis revealed that the soy-receiving group had 80% lower percentage of mammographic densities compared to those receiving the placebo, which was statistically significant. The two groups had statistically different body mass index (BMI) values as the soy-receiving group had 19% higher BMI values than the control group.
Conclusion: The findings indicate that soy consumption has a modest impact on mammographic density percentage, which may hold clinical significance.
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