The pH Levels of Sentinel Lymph Nodes and the Probability of Cancer Involvement in Breast Cancer Patients: a Cross-Sectional Study pH levels of SLN in breast cancer

Maryam Avatefi (1), Zohreh Miripour (2), Fereshte Abasvandi (3), Faeze Aghaei (4), Sepideh Mansouri (5), Seyyed Hossein Miraghaie (6), Parisa Hoseinpour (7), Mohammad Esmaeil Akbari (8), Mohammad Abdolahad (9)
(1) Cancer Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran, Iran, Islamic Republic of,
(2) Nano Bio Electronic Devices Lab, Cancer Electronics Research Group, School of Electrical and Computer Engineering, College of Engineering, University of Tehran, Tehran, Iran; UT&TUMS Cancer Electronics Research Center, Tehran, Iran, Iran, Islamic Republic of,
(3) Cancer Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran; Nano Bio Electronic Devices Lab, Cancer Electronics Research Group, School of Electrical and Computer Engineering, College of Engineering, University of Tehran, Tehran, Iran; ATMP Department, Breast Cancer Research Center, Motamed Cancer Institute, ACECR, Tehran, Iran, Iran, Islamic Republic of,
(4) Nano Bio Electronic Devices Lab, Cancer Electronics Research Group, School of Electrical and Computer Engineering, College of Engineering, University of Tehran, Tehran, Iran, Iran, Islamic Republic of,
(5) UT&TUMS Cancer Electronics Research Center, Tehran, Iran , Iran, Islamic Republic of,
(6) Nano Bio Electronic Devices Lab, Cancer Electronics Research Group, School of Electrical and Computer Engineering, College of Engineering, University of Tehran, Tehran, Iran, Iran, Islamic Republic of,
(7) ATMP Department, Breast Cancer Research Center, Motamed Cancer Institute, ACECR, Tehran, Iran; SEPAS Pathology Lab, Tehran, Iran, Iran, Islamic Republic of,
(8) Cancer Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran, Iran, Islamic Republic of,
(9) Nano Bio Electronic Devices Lab, Cancer Electronics Research Group, School of Electrical and Computer Engineering, College of Engineering, University of Tehran, Tehran, Iran; UT&TUMS Cancer Electronics Research Center, Tehran, Iran , Iran, Islamic Republic of

Abstract

Background: Cancer cells in lymph nodes can undergo metabolic changes, producing acidic byproducts. Our previous experimental results demonstrated significant pH differences between involved and free lymph nodes (LNs), potentially attributed to the release of these acidic byproducts. However, the accuracy of frozen sections is influenced by pathologists' expertise and limited response time. To address these limitations, we developed a simple pH sensing method.


Methods: In this paper, we conduct a cross-sectional study on non-neoadjuvant breast cancer patients (n= 34) from Shohada Tjarish Hospital and Azar Surgical Clinic to check the agreement between the pH value of sentinel lymph nodes (SLNs) and their pathologic score. To assess the pH assay's validity in detecting metastasized cancer cells in lymph nodes, the sensitivity, specificity, and accuracy of the sensor were calculated using Permanent pathology of LNs as the reference standard.


Results: Results showed that cancer SLNs had pH , while free LNs had pH > 8 (p-value <0.001). The sensitivity and specificity of the data were 89% (95% CI (0.73-1.05)) and 82% (95% CI (0.64-1.00)), respectively.


Conclusion: Hence, in the absence of a frozen section, such a simple measurement may assist the surgeon in deciding whether to dissect a further number of LNs or not.

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Authors

Maryam Avatefi
Zohreh Miripour
Fereshte Abasvandi
Faeze Aghaei
Sepideh Mansouri
Seyyed Hossein Miraghaie
Parisa Hoseinpour
Mohammad Esmaeil Akbari
Mohammad Abdolahad
m.abdolahad@ut.ac.ir (Primary Contact)
1.
Avatefi M, Miripour Z, Abasvandi F, Aghaei F, Mansouri S, Miraghaie SH, Hoseinpour P, Akbari ME, Abdolahad M. The pH Levels of Sentinel Lymph Nodes and the Probability of Cancer Involvement in Breast Cancer Patients: a Cross-Sectional Study: pH levels of SLN in breast cancer. Arch Breast Cancer [Internet]. 2024 May 1 [cited 2024 Nov. 21];11(2):191-7. Available from: https://archbreastcancer.com/index.php/abc/article/view/899

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