Effects of Supplementation with Omega-3 Polyunsaturated Fatty Acids as an Adjuvant Therapy in the Treatment of Patients with Breast Cancer: A Systematic Review Effect of omega-3 as adjuvant therapy

Srilaxmi Vityala (1), Krishna Priya Kanteti (2), Yethindra Vityala (3), Altynai Zhumabekova (4), Vipin (5)
(1) College of fishery science, Wanaparthy, Telangana, India , India,
(2) Gandhi Medical College and Hospital, Secunderabad, Telangana, India, India,
(3) International Higher School of Medicine, Bishkek, Kyrgyzstan , India,
(4) City Maternity Hospital No. 2, Bishkek, Kyrgyzstan, Kyrgyzstan,
(5) K. Akhunbaev Kyrgyz State Medical Academy, Bishkek, Kyrgyzstan, India


Background: The association between Omega-3 (n-3) polyunsaturated fatty acid (PUFA) supplementation and breast cancer (BC) prognosis has been shown to be positive, as it plays an important role in cancer treatment, reduces the side effects of therapies, and helps in the preservation of lean mass and weight control. This study aimed to analyze the effects of supplementation with n-3 PUFAs as an adjuvant therapy in the treatment of patients with BC. 

Methods: The following databases were searched electronically: Embase, PubMed, Web of Science, and Google Scholar. The selection criteria were based on the topic's relevancy, which was mentioned as a certain stage of BC and the usage of n-3 PUFA. The first search yielded 62 papers in total; afterwards, 55 publications that didn't meet our eligibility requirements were removed, and eight articles were selected. 

Results: Supplementation with n-3 PUFA varied from 1–4.3 g daily in the studies. By lowering the levels of Ki-67 and vascular endothelial growth factor, it was clear that adding n-3 PUFA to the BC treatment plan slowed the growth of tumors and made people live longer. The brief Pain Inventory and average pain in supplemented women found improvement in arthralgia in both groups in an American clinical trial.

Conclusion: Supplementing with n-3 PUFAs has been shown to help patients with BC in a number of ways, including as an antioxidant, by increasing the survival rate of patients, by reducing side effects, by improving the lipid profile, and by increasing the density of the breasts.


Full text article

Generated from XML file


Godinho-Mota JCM, Gonçalves LV, Mota JF, Soares LR, Schincaglia RM, Martins KA, et al. Sedentary Behavior and Alcohol Consumption Increase Breast Cancer Risk Regardless of Menopausal Status: A Case-Control Study. Nutrients. 2019;11(8):1871. doi: 10.3390/nu11081871.

Madzima TA, Deaterly CD. Body Composition, Metabolism, and Inflammation in Breast Cancer Survivors and Healthy Age-matched Controls: A Cross-Sectional Analysis. Int J Exerc Sci. 2020;13(3):1108–19.

Carneiro BA, El-Deiry WS. Targeting apoptosis in cancer therapy. Nat Rev Clin Oncol. 2020;17(7):395–417. doi: 10.1038/s41571-020-0341-y.

Baskar R, Lee KA, Yeo R, Yeoh KW. Cancer and radiation therapy: current advances and future directions. Int J Med Sci. 2012;9(3):193–9. doi: 10.7150/ijms.3635.

Altun İ, Sonkaya A. The Most Common Side Effects Experienced by Patients Were Receiving First Cycle of Chemotherapy. Iran J Public Health. 2018;47(8):1218–9.

Moradian S, Howell D. Prevention and management of chemotherapy-induced nausea and vomiting. Int J Palliat Nurs. 2015;21(5):218–24. doi: 10.12968/ijpn.2015.21.5.216.

Bruggeman AR, Kamal AH, LeBlanc TW, Ma JD, Baracos VE, Roeland EJ. Cancer Cachexia: Beyond Weight Loss. J Oncol Pract. 2016;12(11):1163–1171. doi: 10.1200/JOP.2016.016832.

Liu J, Ma DW. The role of n-3 polyunsaturated fatty acids in the prevention and treatment of breast cancer. Nutrients. 2014;6(11):5184–223. doi: 10.3390/nu6115184.

Huerta-Yépez S, Tirado-Rodriguez AB, Hankinson O. Role of diets rich in omega-3 and omega-6 in the development of cancer. Bol Med Hosp Infant Mex. 2016;73(6):446–56. doi: 10.1016/j.bmhimx.2016.11.001.

Urrútia G, Bonfill X. PRISMA declaration: a proposal to improve the publication of systematic reviews and meta-analyses. Med Clin (Barc). 2010;135(11):507–11. doi: 10.1016/j.medcli.2010.01.015

Darwito D, Dharmana E, Riwanto I, et al. Effects of Omega-3 Supplementation on Ki-67 and VEGF Expression Levels and Clinical Outcomes of Locally Advanced Breast Cancer Patients Treated with Neoadjuvant CAF Chemotherapy: A Randomized Controlled Trial Report. Asian Pac J Cancer Prev. 2019;20(3):911–16. doi: 10.31557/APJCP.2019.20.3.911.

Paixão EMDS, Oliveira ACM, Pizato N, Muniz-Junqueira MI, Magalhães KG, Nakano EY, et al. The effects of EPA and DHA enriched fish oil on nutritional and immunological markers of treatment naive breast cancer patients: a randomized double-blind controlled trial. Nutr J. 2017;16(1):71. doi: 10.1186/s12937-017-0295-9.

Hutchins-Wiese HL, Picho K, Watkins BA, Li Y, Tannenbaum S, Claffey K, et al. High-dose eicosapentaenoic acid and docosahexaenoic acid supplementation reduces bone resorption in postmenopausal breast cancer survivors on aromatase inhibitors: a pilot study. Nutr Cancer. 2014;66(1):68–76. doi: 10.1080/01635581.2014.847964

Shen S, Unger JM, Crew KD, Till C, Greenlee H, Gralow J, et al. Omega-3 fatty acid use for obese breast cancer patients with aromatase inhibitor-related arthralgia (SWOG S0927). Breast Cancer Res Treat. 2018;172(1):603–10. doi: 10.1007/s10549-018-4946-0

Hershman DL, Unger JM, Crew KD, Awad D, Dakhil SR, Gralow J, et al. Randomized Multicenter Placebo-Controlled Trial of Omega-3 Fatty Acids for the Control of Aromatase Inhibitor-Induced Musculoskeletal Pain: SWOG S0927. J Clin Oncol. 2015;33(17):1910–17. doi: 10.1200/JCO.2014.59.5595.

de la Rosa Oliva F, Meneses García A, Ruiz Calzada H, Astudillo de la Vega H, Bargalló Rocha E, Lara-Medina F, et al. Effects of omega-3 fatty acids supplementation on neoadjuvant chemotherapy-induced toxicity in patients with locally advanced breast cancer: a randomized, controlled, double-blinded clinical trial. Nutr Hosp. 2019;36(4):769–76. doi: 10.20960/nh.2338.

Sandhu N, Schetter SE, Liao J, Hartman TJ, Richie JP, McGinley J, et al. Influence of Obesity on Breast Density Reduction by Omega-3 Fatty Acids: Evidence from a Randomized Clinical Trial. Cancer Prev Res (Phila). 2016;9(4):275–82. doi: 10.1158/1940-6207.CAPR-15-0235.

Lustberg MB, Orchard TS, Reinbolt R, Andridge R, Pan X, Belury M, et al. Randomized placebo-controlled pilot trial of omega 3 fatty acids for prevention of aromatase inhibitor-induced musculoskeletal pain. Breast Cancer Res Treat. 2018;167(1):709–18. doi: 10.1007/s10549-017-4559-z.

Tajan M; Vousden KH. Dietary Approaches to Cancer Therapy. Cancer Cell. 2020;37(6):767–85. doi: 10.1016/j.ccell.2020.04.005.


Srilaxmi Vityala
Krishna Priya Kanteti
Yethindra Vityala
yethindravityala10@gmail.com (Primary Contact)
Altynai Zhumabekova
Author Biographies

Srilaxmi Vityala, College of fishery science, Wanaparthy, Telangana, India



Krishna Priya Kanteti, Gandhi Medical College and Hospital, Secunderabad, Telangana, India



Yethindra Vityala, International Higher School of Medicine, Bishkek, Kyrgyzstan

Department of Pathology


Altynai Zhumabekova, City Maternity Hospital No. 2, Bishkek, Kyrgyzstan



Vipin, K. Akhunbaev Kyrgyz State Medical Academy, Bishkek, Kyrgyzstan



Vityala S, Kanteti KP, Vityala Y, Zhumabekova A, Vipin. Effects of Supplementation with Omega-3 Polyunsaturated Fatty Acids as an Adjuvant Therapy in the Treatment of Patients with Breast Cancer: A Systematic Review: Effect of omega-3 as adjuvant therapy. Arch Breast Cancer [Internet]. 2023 Sep. 11 [cited 2024 Jul. 16];10(4):323-30. Available from: https://archbreastcancer.com/index.php/abc/article/view/765

Article Details