Fibromatosis of the Breast: Report of a Case with Cytohistological Correlation Fibromatosis of the Breast

Helen J Trihia (1), Dimitrios Kouzos (2), Efthymia Souka (3), Marianthi Moundrea (4), Panagiotis Manikis (5), Ioannis Provatas (6)
(1) Departments of Pathology, Metaxas Memorial Cancer Hospital, Piraeus, Greece, Greece,
(2) Departments of Pathology, Metaxas Memorial Cancer Hospital, Piraeus, Greece, Greece,
(3) Departments of Pathology, Metaxas Memorial Cancer Hospital, Piraeus, Greece, Greece,
(4) Radiology, Metaxas Memorial Cancer Hospital, Piraeus, Greece, Greece,
(5) Department of Surgery, Metaxas Memorial Cancer Hospital, Piraeus, Greece, Greece,
(6) Department of Pathology, District General Hospital of Nikaia Agios Panteleimon, Piraeus, Greece, Greece

Abstract

Background: Breast fibromatosis is a very rare, locally infiltrative lesion, without metastatic potential that arises from either stromal fibroblasts or myofibroblasts of the breast or from the pectoral fascia, extending into the breast, with its cytological and histological features only rarely being described.


Case Presentation: A 58-year-old woman, with no past medical/surgical or family history, was diagnosed on regular mammographic and ultrasound examination with a nodular tumor density, in the upper inner part of her right breast. There were no calcifications or apparent lymph nodes in the right axilla. The woman underwent FNA and US-guided biopsy and final resection biopsy under hook marking. We reviewed the cytological findings of fibromatosis of the breast, as they presented in FNAC aspirates of a non-palpable mammographic finding and the histological findings in both preoperative core-needle biopsy and excision specimen. The final diagnosis was of fibromatosis of the breast. No further actions were taken. The woman is well, without recurrence, more than four years afterwards.


Conclusion: Our case can make the pathologists more acquainted with the cytological and pathologic features of a rare tumor entity and the clinicians with a rare breast lesion, which can mimic malignancy both clinically and radiologically. The diagnosis of fibromatosis of the breast is more reliable in excision specimens. Nevertheless, cytology can be an invaluable adjunct to histology, pre-operatively, as it can exclude cancer and help in the preoperative planning.  

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Authors

Helen J Trihia
Dimitrios Kouzos
Efthymia Souka
Marianthi Moundrea
Panagiotis Manikis
Ioannis Provatas
iannispro@yahoo.co.uk (Primary Contact)
Author Biographies

Dimitrios Kouzos, Departments of Pathology, Metaxas Memorial Cancer Hospital, Piraeus, Greece

Department of Pathology, 'Metaxas' Memorial Cancer Hospital, Piraeus, Greece

Efthymia Souka, Departments of Pathology, Metaxas Memorial Cancer Hospital, Piraeus, Greece

Department of Pathology, 'Metaxas' Memorial Cancer Hospital, Piraeus, Greece

Marianthi Moundrea, Radiology, Metaxas Memorial Cancer Hospital, Piraeus, Greece

Department of Radiology, 'Metaxas' Memorial Cancer Hospital, Piraeus, Greece

1.
TRIHIA HJ, Kouzos D, Souka E, Moundrea M, Manikis P, Provatas I. Fibromatosis of the Breast: Report of a Case with Cytohistological Correlation: Fibromatosis of the Breast. Arch Breast Cancer [Internet]. 2022 Mar. 4 [cited 2024 Apr. 22];9(2):240-6. Available from: https://archbreastcancer.com/index.php/abc/article/view/527

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