Pure Mucinous Breast Carcinoma with Micropapillary Pattern in a 32-Year-Old Female

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Nahid Sadighi
razieh shahnazari
Fariba Asadi


Breast, Mucinous Carcinoma, Pure type, Mixed type


Background: Mucinous carcinoma (MC) is a rare breast malignancy with a large extracellular mucin secretion. It has a good prognosis in comparison to other breast malignancies. 

Case presentation: We report a 32 years old female with multiple hard palpable masses in the left breast with rapid growth in 6 months. She was mentally retarded with lower limb varicose veins associated with mucocutaneous lesions on the face. She underwent ultrasound examination of the breast, thyroid and lower extremity veins. Core needle biopsy and fine needle aspiration from left breast lesions and right thyroid nodules showed MC and follicular lesion with hurtle cell change, respectively. Suspected metastasis in the left rib and calvarium in the subsequent bone scan survey and brain magnetic resonance imaging was reported. She underwent radical mastectomy and right hemi-thyroidectomy.

Conclusion: Pure mucinous carcinoma with micropapillary pattern (MUMPC) is a new histology variant of Pure Mucinous Carcinoma (PMC) that shows favorable prognosis with less aggression and occurs in older patients. However, PMC in our patient occurred at a young age with greater aggression.


1. Luna-Abanto J, Mendoza Tisoc G. Mucinous carcinoma of the breast: a case report and review of the literature. Medwave. 2017;17(6):e7003.
2. Bitencourt AG, Graziano L, Osorio CA, Guatelli CS, Souza JA, et al. MRI Features of Mucinous Cancer of the Breast: Correlation With Pathologic Findings and Other Imaging Methods. AJR Am J Roentgenol. 2016;206(2):238-46.
3. Chaudhry AR, El Khoury M, Gotra A, Eslami Z, Omeroglu A, et al. Imaging features of pure and mixed forms of mucinous breast carcinoma with histopathological correlation. Br J Radiol. 2019;92(1095):20180810.
4. Iqbal BM, Banerjee B. Mucinous carcinoma of breast in a 30-year-old female: A rare case report and discussion. Clin Cancer Investig J. 2016;5(5):489.
5. Asano Y, Kashiwagi S, Nagamori M, Tanaka S, Kuwae Y, et al. Pure Mucinous Breast Carcinoma with Micropapillary Pattern (MUMPC): A Case Report. Case Rep Oncol. 2019;12(2):554-9.
6. Davies N, Duff M. Breast cancer screening for older women with intellectual disability living in community group homes. J Intellect Disabil Res. 2001;45(Pt 3):253-7.
7. Satgé D, Sauleau E-A, Jacot W, Raffi F, Azéma B, et al. Age and stage at diagnosis: a hospital series of 11 women with intellectual disability and breast carcinoma. BMC cancer. 2014;14(1):1-6.
8. Truesdale‐Kennedy M, Taggart L, McIlfatrick S. Breast cancer knowledge among women with intellectual disabilities and their experiences of receiving breast mammography. J Adv Nurs. 2011;67(6):1294-304.
9. Eng C. Will the real Cowden syndrome please stand up: revised diagnostic criteria. J Med Genet. 2000;37(11):828-30.
10. Dumitru A, Procop A, Iliesiu A, Tampa M, Mitrache L, et al. Mucinous Breast Cancer: a Review Study of 5 Year Experience from a Hospital-Based Series of Cases. Maedica (Bucur). 2015;10(1):14-8.
11. Chen WZ, Shen JF, Zhou Y, Chen XY, Liu JM, et al. Clinical characteristics and risk factors for developing bone metastases in patients with breast cancer. Sci Rep. 2017;7(1):11325.
12. Dogan E, Aksoy S, Dizdar O, Arslan C, Dede DS, et al. Pure mucinous carcinoma of the breast: a single center experience. J BUON. 2011;16(3):565-7.

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