Novel Approach Exploiting the Hyperspectral Imaging System for Breast Cancer Therapy and Diagnosis

Mohamed Hisham Fouad Aref (1), Ibrahim H. Aboughaleb (2), Abou-Bakr M. Youssef (3), Yasser H. El-Sharkawy (4)
(1) Biomedical Engineering Department, Military Technical College, Cairo, Egypt, Egypt,
(2) Biomedical Engineering Department, Military Technical College, Cairo, Egypt, Egypt,
(3) System & Biomedical Engineering Department, Cairo University, Giza, Egypt, Egypt,
(4) Biomedical Engineering Department, Military Technical College, Cairo, Egypt, Egypt
https://doi.org/10.32768/abc.202074189-201

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Issue
Vol 7, No 4: November 2020
Submitted
October 8, 2020
Published
November 16, 2020
Keywords:
    Breast Cancer; Hyperspectral Imaging System; Tissue Optical Properties; Breast Diagnosis & Therapy; Optical Spectroscopy.
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Abstract

Background: Breast malignant growth is the most widely recognized disease in women in both highly and less developed nations where early detection is vital for life-saving and fast recovery. Recently, Photonic technologies has played a vital role in medical applications. Their satisfactory and viable implementation in therapy and diagnosis requires reliable information on the optical properties of human tissues. This study presents an outline of recent outcomes on the magnitude of breast tissue optical properties.
Methods: We established two different system setups utilizing hyperspectral (HS) camera and multiple excitation source lights with wavelength (380~1050 nm) for this investigation. The first setup (Transmission Mode) was applied for light transmission measurement of ex-vivo breast sample. Thereby, we made calculations of sample absorption. The second setup (Reflection Mode) was used for the measurement of breast sample light diffuse reflectance. The outcomes of both setups were used to select the optimum spectral image to differentiate between the normal and tumoral regions in the ex-vivo breast sample by exploring the optical properties spectroscopy in the Near and visible (NIR-VIS) spectrum. Finally, we applied the custom system on the case study technique for breast tumor detection.
Results: Experimental investigations results showed that due to the various excitation wavelength light source (380~1050 nm) generates variable depths of penetration depth in the ex-vivo breast sample. Consequently, experimental results of the diffuse reflectance (?d) provide the optimum spectral image at 600 nm for the diagnostic applications. However, the statistical calculation of the normalized signal validated the outcome at wavelength 680 nm. Additionally, we noticed the optimum spectral image for therapy applications at 700 nm by measurement of breast tissue transmission (?) and attenuation absorption (?) calculation. Moreover, the statistical calculation of the normalized signal validated the outcome at wavelength 760 nm.
Conclusions: The proposed novel approach successfully provided promising results of the investigated breast sample optical properties in both diagnostic and therapy applications to assist the pathologist and the surgeon. The trail outcomes of the investigated case study were impressive for selecting optimum wavelength for diagnostic and treatment (680, 760 nm), respectively.

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Authors

Mohamed Hisham Fouad Aref
Biomedical Engineering Department, Military Technical College, Cairo, Egypt
https://orcid.org/0000-0001-7847-4984
mh-aref@ieee.org (Primary Contact)
Ibrahim H. Aboughaleb
Biomedical Engineering Department, Military Technical College, Cairo, Egypt
https://orcid.org/0000-0002-7445-3040
Abou-Bakr M. Youssef
System & Biomedical Engineering Department, Cairo University, Giza, Egypt
Yasser H. El-Sharkawy
Biomedical Engineering Department, Military Technical College, Cairo, Egypt
https://orcid.org/0000-0002-0551-7282
Author Biographies

Mohamed Hisham Fouad Aref, Biomedical Engineering Department, Military Technical College, Cairo, Egypt

Mohamed Hisham Aref is PhD Candidate at Military Technical College, Biomedical Engineering department. He received his BS degree in Biomedical Engineering from Military Technical College in 2006 and his MS degree from Cairo University, Faculty of engineering in 2012, respectively, He is highly skilled & talented biomedical engineer with more than 14 years of practical experience in the design & improvement of the medical equipment’s disease diagnosis, treatments & preventions. His current PhD topic in “Monitoring & Control of Tumor Thermal Ablation using Advanced Ultrasound Imaging Technologies. His current research interests include Thermal Ablation, US imaging technologies, Cancer Early detection, Medical Gases Design, Hyperbaric Oxygen Therapy. He is a member of IEEE.

Abou-Bakr M. Youssef, System & Biomedical Engineering Department, Cairo University, Giza, Egypt

Abou-Bakr M. Youssef was born in Cairo Egypt 1951. He graduated from Cairo University—Faculty of Engineering—Electrical Engineering & Communication Department with Distinction with Honor in 1974. Then, he joined the Faculty of Medicine and worked in parallel on engineering research and received M.S.E.E. degree in 1978, and the Ph.D. degree in biomedical engineering (MIT fellow) in 1982—Cairo University. While continuing his engineering career, he was also able to graduate from the Medical School, Cairo University 1980, and earned the MBBH, Distinction with Honors, and the foreign equivalent, ECFMG, in 1981. In 1984, he received the M.S. degree in radiology from Cairo University, and the MD degree from Heildelberg University, Heildelberg, Germany, in 1989. He conducted medical research in the German cancer research center (DKFZ) from 1987–1993.,He contributed to the establishment of the Biomedical Engineering Department at Cairo University in 1977, developed courses of biomedical equipment and clinical engineering as well as medical imaging, and joined in the establishment of the Technology Transfer Focus in Medical School-Cairo University, in cooperation with the National Science Foundation in 1978–1980. He gained clinical experience in his research and educational life span by working as the Head of the Ultrasound Department in major hospitals in Cairo as well as within private clinics. In 1990–1992, he participated in the Health Care Development Plan, in cooperation with the Egyptian Scientific Research Academy, Cairo. Many of his researches were published in international and local scientific magazines.,Dr. Youssef was registered as a Diagnostic Medical Sonographer RDMS in 1995. As a member of the American Institute of Ultrasonography in Medicine (AIUM), in 1997 he was elected as a Senior Member. He established the Biomedical Division of International Electronics, as a practical and technical service provider for medical industry and health care community in 1991. He was appointed CEO for International Electronic Company Biomedical group, Cairo. He participated with the Information & Decision Support Center—Egyptian Council of Ministers, in the release of medical software and expert systems in 1994. He was awarded from the government twice for the scientific research—Cairo University 1998, and the national award for advanced technological sciences—2001.

Yasser H. El-Sharkawy, Biomedical Engineering Department, Military Technical College, Cairo, Egypt

Yasser H. El-Sharkawy is professor and Head of Biomedical Engineering department at Military Technical College. He received his BS and MS degrees in physics from the University of Optics in 1993 and 1996, respectively, and his PhD degree in optics from the Institute of Laser and Technology in 2006.  He is the author of more than 54 journal papers. His current research interests include photo acoustic imaging used for breast cancer detection, Biophysics and Medical Physics, Medical Imaging and analysis, Biomedical Engineering.

1.
Aref M, Aboughaleb IH, Youssef A-B, El-Sharkawy Y. Novel Approach Exploiting the Hyperspectral Imaging System for Breast Cancer Therapy and Diagnosis. Arch Breast Cancer [Internet]. 2020 Nov. 16 [cited 2024 Nov. 21];:189-201. Available from: https://archbreastcancer.com/index.php/abc/article/view/326
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