Genetic Counseling in the Follow-up of Breast Cancer patients; Conversion of a Luminal Tumor to TNBC

Hamid Ahmadi (1), Reza Hosseinpour (2), Behnaz Jahanbin (3), Keivan Majidzadeh-A (4), Farid Azmoudeh-Ardalan (5)
(1) , Iran, Islamic Republic of,
(2) Department of Surgery, Tehran University of Medical Sciences, Tehran, Iran, Iran, Islamic Republic of,
(3) Department of Pathology, Tehran University of Medical Sciences, Tehran, Iran, Iran, Islamic Republic of,
(4) Department of Genetics, Breast Cancer Research Center, Motamed Cancer Institute, ACECR, Tehran, Iran, Iran, Islamic Republic of,
(5) Department of Pathology, Tehran University of Medical Sciences, Tehran, Iran, Iran, Islamic Republic of

Abstract

Background: Triple-negative subtype does not have any of the receptors that are commonly found in breast cancer. Patients suffering from Triple-negative breast cancer are at risk of early metastasis and BRCA mutation. The conversion of the receptors during the metastatic progression or local recurrence of breast cancer is a well-known topic that affects the therapeutic measures and outcome. Confirmation of immunohistochemistry is essential in these conditions, but genetic evaluation is controversial.
Case presentation: A woman suffering from primary luminal breast cancer presented with femoral bone metastasis in the follow-up after two years. Bone metastasis was compatible with the triple-negative subtype. This case was discussed at the weekly breast multidisciplinary team session of the Department of Breast Surgery, Tehran University of Medical Sciences.
Question: Does the patient need genetics counseling in a conversion setting? And does the new specimen need CISH/FISH techniques to confirm TNBC tumors?
Conclusion: There are no strong guidelines to recommend genetic counseling and BRCA testing for patients with breast cancer biomarkers conversion. Re-assessing the specimen for ER, PR, and HER-2 is necessary for this setting.

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References

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Authors

Hamid Ahmadi
Reza Hosseinpour
Behnaz Jahanbin
Keivan Majidzadeh-A
Farid Azmoudeh-Ardalan
azmoudeh@sina.tums.ac.ir (Primary Contact)
1.
Ahmadi H, Hosseinpour R, Jahanbin B, Majidzadeh-A K, Azmoudeh-Ardalan F. Genetic Counseling in the Follow-up of Breast Cancer patients; Conversion of a Luminal Tumor to TNBC. Arch Breast Cancer [Internet]. 2020 Feb. 29 [cited 2024 Jul. 16];:10-3. Available from: https://archbreastcancer.com/index.php/abc/article/view/278

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