Can Color and Spectral Doppler Ultrasound of Breast Cancers Help to Predict the Immunohistochemistry profile?

Afsaneh Alikhassi (1), Soodabeh Zamani Nokandeh (2), Kazem Mousavi (3), Hana Saffar (4), Masoumeh Gity (5), Nasrin Ahmadinejad (6)
(1) Department of Radiology, Cancer Institute, Imam Khomeini Hospital, Tehran University of Medical Sciences, Tehran, Iran, Iran, Islamic Republic of,
(2) Department of Radiology, Tehran, University of Medical Science, Tehran, Iran, Iran, Islamic Republic of,
(3) Department of Radiology, Tehran, University of Medical Science, Tehran, Iran, Iran, Islamic Republic of,
(4) Department of Anatomical and Clinical Pathology, Cancer Institute, Imam Khomeini Hospital, Tehran University of Medical Sciences, Tehran, Iran, Iran, Islamic Republic of,
(5) Department of Radiology, Medical Imaging Center, Tehran University of Medical Sciences, Tehran, Iran, Iran, Islamic Republic of,
(6) Department of Radiology, Cancer Institute, Imam Khomeini Hospital, Tehran University of Medical Sciences, Tehran, Iran, Iran, Islamic Republic of

Abstract

 


Purpose: To determine the relationship between color and spectral Doppler features of breast cancers and their biomarkers.


Patients and Methods: From January 2017 to January 2018, 43 patients with breast cancer were enrolled. Age, existence of color flow in the Doppler ultrasound, color flow pattern, tumor size, and immunohistochemistry (IHC) subtypes were recorded.


Results: Among 43 breast cancer patients, IHC profiles showed that 36 patients were estrogen (ER) positive, 30 patients were progesterone (PR) positive, and 12 patients were human epidermal growth factor receptor 2 (Her2) positive. The prevalence of biomarker groups in this study were as follows: luminal A, 21 patients (48.83%); luminal B, 15 (34.88%); Her 2 amplifier, 2 (4.65%); and triple negative, 5 (11.62%). Thirty-seven patients (86.04%) with malignant masses had detectable flow and six patients (13.95%) had no detectable flow. The ER-positive and PR-positive breast cancers had the highest vascular presence rate in color Doppler ultrasound but it was not statistically significant. Maximum vessel diameter in different biomarker groups and Doppler color patterns with various biomarkers showed no significant differences.


Conclusion: It is not possible to predict breast cancer biomarker groups using available color Doppler features and indexes, so pathology with IHC is still required.


 

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Authors

Afsaneh Alikhassi
afsanehalikhassi@yahoo.co.uk (Primary Contact)
Soodabeh Zamani Nokandeh
Kazem Mousavi
Hana Saffar
Masoumeh Gity
Nasrin Ahmadinejad
Author Biography

Afsaneh Alikhassi, Department of Radiology, Cancer Institute, Imam Khomeini Hospital, Tehran University of Medical Sciences, Tehran, Iran

Radiology Department Assistant Professor

1.
Alikhassi A, Zamani Nokandeh S, Mousavi K, Saffar H, Gity M, Ahmadinejad N. Can Color and Spectral Doppler Ultrasound of Breast Cancers Help to Predict the Immunohistochemistry profile?. Arch Breast Cancer [Internet]. 2019 Nov. 30 [cited 2024 May 18];:161-7. Available from: https://archbreastcancer.com/index.php/abc/article/view/268

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