Warfarin Induced Necrosis of The Breast: A Case Report

Sanaz Zand (1), Roghayye Jalili (2), Seyed Hasan Emami Razavi (3), Massoome Najafi (4), Ahmad Kaviani (5)
(1) Department of Research, Kaviani Breast Disese Institute (KBDI), Tehran, iran AND Technical editor, Archives of Breast Cancer, Iran, Islamic Republic of,
(2) Department of Surgery, Tehran University of Medical Sciences, Tehran, Iran, Iran, Islamic Republic of,
(3) Department of Surgery, Tehran University of Medical Sciences(TUMS), Tehran, Iran AND International Center for Surgical Safety (ICSS), St. Michael Hospital, University of Toronto, Canada, Iran, Islamic Republic of,
(4) Department of Surgery, Tehran University of Medical Sciences(TUMS), Tehran, Iran AND International Center for Surgical Safety (ICSS), St. Michael Hospital, University of Toronto, Canada, Iran, Islamic Republic of,
(5) Department of Surgery, Tehran University of Medical Sciences, Tehran, Iran AND Department of Research, Kaviani Breast Diseases Institute, Tehran, Iran, Iran, Islamic Republic of
https://doi.org/10.32768/abc.201854189-191

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Issue
Vol 5, No 4: November 2018
Submitted
November 24, 2018
Published
November 30, 2018
Keywords:
    Warfarin, Breast necrosis, Breast gangrene, Oral anticoagulant therapy
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Abstract

Background: Warfarin induced breast necrosis is a rare complication of oral anticoagulant therapy. Although it can be related to protein C, S, and antithrombin III deficiency; the pathogenesis of necrosis is still unknown.


Case presentation: We report a case of a 38-year-old woman with extensive left breast necrosis after receiving warfarin for treatment of deep vein thrombosis. Simple mastectomy was performed and the wound was closed secondarily with an abdominal advancement flap. Rivaroxaban was prescribed after discontinuation of warfarin.


Conclusion: Although breast necrosis following warfarin usage is uncommon, it should be considered in women presenting with breast symptoms after initiation of warfarin. Early diagnosis and appropriate management are essential to prevent extensive loss of breast tissue.

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Authors

Sanaz Zand
Department of Research, Kaviani Breast Disese Institute (KBDI), Tehran, iran AND Technical editor, Archives of Breast Cancer
Roghayye Jalili
Department of Surgery, Tehran University of Medical Sciences, Tehran, Iran
Seyed Hasan Emami Razavi
Department of Surgery, Tehran University of Medical Sciences(TUMS), Tehran, Iran AND International Center for Surgical Safety (ICSS), St. Michael Hospital, University of Toronto, Canada
Massoome Najafi
Department of Surgery, Tehran University of Medical Sciences(TUMS), Tehran, Iran AND International Center for Surgical Safety (ICSS), St. Michael Hospital, University of Toronto, Canada
mdmasoume@yahoo.com (Primary Contact)
Ahmad Kaviani
Department of Surgery, Tehran University of Medical Sciences, Tehran, Iran AND Department of Research, Kaviani Breast Diseases Institute, Tehran, Iran
1.
Zand S, Jalili R, Emami Razavi SH, Najafi M, Kaviani A. Warfarin Induced Necrosis of The Breast: A Case Report. Arch Breast Cancer [Internet]. 2018 Nov. 30 [cited 2024 Nov. 22];:189-91. Available from: https://archbreastcancer.com/index.php/abc/article/view/226
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