The Bench of Primary Breast Lymphoma Treatment: A Review of the Literature and a Case Report

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Saeed Karimkhani Zandi
Fatemeh Heidari


Breast lymphoma, Primary breast lymphoma (PBL), Diffuse large B-cell lymphoma (DLBCL)


Background: Primary non-Hodgkin breast lymphoma is a rare pathology, representing 0.5 percent of malignant breast tumors.
Case Presentation: Here, we report a 54-year-old female presenting a mass in the left breast diagnosed by needle biopsy and IHC as a diffuse large B-cell lymphoma (DLBCL). Radiation therapy with conventional fields was applied for whole breast irradiation after the patient received 6 courses of R-CHOP (Rituximab plus Cyclophosphamide, Doxorubicin, Vincristine, and Prednisolone) chemotherapy. At the follow-up period 11 months after radiation therapy, no morbidities occurred and the patient is surviving with no evidence of disease.
Conclusions: The common treatments for breast lymphomas are surgery, radiation therapy, and chemotherapy. Although no agreement has been reached on the best therapy for primary breast lymphomas, these methods are commonly applied alone or in combination. It seems that R-CHOP combined with radiation therapy regimen could be an important treatment modality in avoiding unnecessary surgery.

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