Immunohistochemical Expression of B-Cell Lymphoma-2 Gene with Clinicopathological Correlation: A Comparative Analysis of Triple Negative and Non-Triple Negative Breast Cancers

Muhammad Zubair (1), Iqbal Muhammad (2), Hassan Tariq (3), Rabia Ahmad (4), Akhter Ali (5), Salma Gul (6)
(1) Consultant Histopathologist, Histopathology department, Armed Forces Institute of Pathology, Rawalpindi, Pakistan,
(2) Consultant Histopathologist, Histopathology department, Armed Forces Institute of Pathology, Rawalpindi, Pakistan,
(3) Resident of Histopathology, Histopathology department, Armed Forces Institute of Pathology, Rawalpindi, Pakistan,
(4) Consultant Histopathologist, Histopathology department, Armed Forces Institute of Pathology, Rawalpindi, Pakistan,
(5) Resident of Histopathology, Histopathology department, Armed Forces Institute of Pathology, Rawalpindi, Pakistan,
(6) Department of Pathology, Khyber Medical University, Peshawar, Pakistan

Abstract

Background: B-Cell Lymphoma-2 gene is an anti-apoptotic protein associated with favorable prognosis in patients with breast cancer. The present study focused on immunohistochemical expression of the aforementioned gene with clinicopathological correlation in non-triple negative breast cancers (NTNBCs) and triple negative breast cancers (TNBCs).


Methods: We investigated 258 cases of primary breast cancers; they were divided into 2 groups (NTNBCs and TNBCs) based on their expression of estrogen receptor (ER), progesterone receptors (PR), and Her-2/neu receptors. BCL-2 expression was correlated with age, tumor size, tumor grade, histological subtype, lymph node status, and lymphovascular invasion (LVI).


Results: Among NTNBCs, 68.2% of cases expressed BCL-2 as compared to 53.3% in TNBCs (P-value = 0.035). In both groups, BCL-2 expression was significantly higher in younger patients, without lymphovascular invasion and lower grade (borderline significant in TNBCs). The variable which was associated with higher BCL-2 expression only in NTNBCs was smaller tumor size. In contrast, in TNBCs invasive ductal carcinoma was significantly associated with BCL-2 expression.


Conclusions: BCL-2 showed association with various clinicohistopathological characteristics in TNBC and NTNBC breast cancer patients. Yet, some of these variables were potentially related to better prognosis (the lack of LVI, smaller tumor size, and lower grade). On the other hand, younger age, which is a feature generally associated with poorer prognosis, was significantly related to BCL-2 expression.

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Authors

Muhammad Zubair
mzubair84@hotmail.com (Primary Contact)
Iqbal Muhammad
Hassan Tariq
Rabia Ahmad
Akhter Ali
Salma Gul
Author Biographies

Muhammad Zubair, Consultant Histopathologist, Histopathology department, Armed Forces Institute of Pathology, Rawalpindi, Pakistan

Consultant Histopathologist.

Iqbal Muhammad, Consultant Histopathologist, Histopathology department, Armed Forces Institute of Pathology, Rawalpindi, Pakistan

Cosultant Head of Histopathology department

Hassan Tariq, Resident of Histopathology, Histopathology department, Armed Forces Institute of Pathology, Rawalpindi, Pakistan

Resident Histopathology

Rabia Ahmad, Consultant Histopathologist, Histopathology department, Armed Forces Institute of Pathology, Rawalpindi, Pakistan

Consultant Histopathologist

Akhter Ali, Resident of Histopathology, Histopathology department, Armed Forces Institute of Pathology, Rawalpindi, Pakistan

Resident Histopathology

Salma Gul, Department of Pathology, Khyber Medical University, Peshawar, Pakistan

Pathology Department
1.
Zubair M, Muhammad I, Tariq H, Ahmad R, Ali A, Gul S. Immunohistochemical Expression of B-Cell Lymphoma-2 Gene with Clinicopathological Correlation: A Comparative Analysis of Triple Negative and Non-Triple Negative Breast Cancers. Arch Breast Cancer [Internet]. 2017 Jun. 13 [cited 2024 May 28];4(2):58-63. Available from: https://archbreastcancer.com/index.php/abc/article/view/130

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