Association of Lipid Profile Markers with Breast Cancer: An Analysis of the KFSH Study in Dammam, KSA Lipid profile markers in BC
Abstract
Background: Breast cancer (BC) is a heterogeneous disease characterized by the presence of a lump or mass in the breast tissue. BC has been associated with an abnormal lipid profile; however, this relationship is controversial. This study investigated the relationship of circulating lipid profiles with BC among Saudi women attending King Fahad Specialist Hospital, Dammam (KFSH-D), KSA.
Methods: Three hundred and ninety-nine (399) women between the years 2018 and 2021 were selected for this case control study based on the presence (for cases) or absence (for controls) of BC at the KFSH-D. The lipid levels of women with BC were compared to the lipid levels of healthy women. Data on total cholesterol (TC), triglyceride (TG), high-density lipoproteins (HDL), and low-density lipoproteins (LDL) were collected from 200 BC diagnosed patients and 199 healthy individuals. Statistical analysis was performed using the t-test and regression analysis.
Results: This study showed significant differences between BC patients and healthy controls in terms of total cholesterol, HDL, and TG levels. No significant difference was observed in LDL levels.
Conclusion: This study revealed a significant relationship between the circulating lipid profile and breast cancer in a cohort of Saudi women.
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References
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