_1638003546 1638003546 brea akaviani@archbreastcancer.com Farname Inc Archives of Breast Cancer Arch Breast Cancer 2383-0433 10 31 2021 Mohammad Naser Athamnah Shatha M. Al-Barrak Nimah A. Rabai Tea Natelauri Hussein S O Al Azzam Mohammed Alorjani Omar M. Al-Rusan Amer Abu-Shanab Background: Spindle cell carcinoma (SpCC) is an unusual form of squamous cell carcinoma (SCC) and can sometimes present in the breast. Owing to the rarity of breast SpCC, few case studies are available nowadays and proper evidence is scarce.  Case presentation: We herein report a 60-year-old female patient, who was referred to the surgery services after presenting with a right breast ulcerated mass. On physical examination, a 7x7 cm mass was found along with a 3 cm ulcer on the top of it. Both mammography and ultrasound showed a dense mass, and tru-cut and skin punch biopsies confirmed neoplastic spindle cells within the lesion. The patient underwent a right total mastectomy with sentinel lymph node biopsies with no further chemotherapy or radiotherapy. Conclusion: Owing to the heterogeneity of SpCC, there is no exact treatment protocol for this type of cancer, and mastectomy or conservative surgery can be performed in certain groups of patients depending on tumor size, stage, and lymph node involvement. Fortunately, promising medical and biological therapies might be of use in the near future. 10 31 2021 350 357 http://creativecommons.org/licenses/by-nc/4.0 10.32768/abc.202184350-357 https://www.archbreastcancer.com/index.php/abc/article/view/430 https://www.archbreastcancer.com/index.php/abc/article/download/430/577 https://www.archbreastcancer.com/index.php/abc/article/download/430/577