Anaplastic Large Cell Lymphoma Associated with Saline Breast Implant

Grace Ng, Rupa K. Patel, LaNette Smith, Guido Sclabas


Background: Breast implant associated anaplastic large T- cell lymphoma is a rare type of non-Hodgkin lymphoma, with a reported incidence of 0.3% per 100,000 women with breast prosthesis per year. It presents most commonly as a peri-implant seroma, but may also present as a capsular mass, tumor erosion through skin, in a regional lymph node, or found incidentally during revision surgery.

Case presentation: We report a 68-year-old female patient who presented with a four month history of marked pain and swelling of the right breast, who upon implant removal and right sided capsulectomy, revealed pathology consistent with ALK negative, CD 30 positive anaplastic large T- cell lymphoma.

Conclusion: Breast implant associated anaplastic large cell lymphoma, although a rare clinical occurrence is of clinical significance. Prognosis is favorable in the majority of reported cases. Definitive treatment guidelines have yet to be determined after review of long-term follow-up data.


breast lymphoma; breast implant; seroma

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                                     Archives of Breast Cancer, eISSN: 2383-0433, pISSN: 2383-0425